Endocannabinoid System Explained – How Does It Work?
The endocannabinoid system plays a significant role in how the human body interacts with hemp. Hemp and cannabis are versatile plants used by millions of people around the globe for different purposes. Every effect that CBD and THC have on the human body is thanks to the endocannabinoid system.
What Is the Endocannabinoid System?
How Homoeostasis Works
Cannabinoid Receptors Within the Endocannabinoid System
The two major cannabinoid receptors in the endocannabinoid system are CB1 and CB2 receptors. They are not the only cannabinoid receptors in the endocannabinoid system, but they were the first ones to be discovered and, as a result, are the best understood.
- Cannabinoid receptors lie on cell surfaces throughout the body. They transmit information about changing conditions to the cell’s inside. This, in turn, sparks a cellular response.
- The two major cannabinoid receptors in the endocannabinoid system are CB1 and CB2 receptors. They are not the only cannabinoid receptors in the endocannabinoid system, but they were the first ones to be discovered and, as a result, are the best understood.
A few examples of cannabinoids include:
2-Arachidonoyl glycerol (2-AG)
How the Endocannabinoid System Regulates Neurons
How Endocannabinoids Work Within the Brain
Regulating Inflammation with Endocannabinoids
How Do THC and CBD Interact with the Endocannabinoid System?
- THC induces a temporary high because it activates the CB1 receptors located within the brain. It does not interact with CB1 receptors in the same way that natural endocannabinoids do: Metabolic enzymes that would normally break down endocannabinoids after they are used do not work on THC, so THC lingers for a longer period of time.
- CBD, the most common non-psychoactive cannabinoid found hemp and cannabis, interacts with various receptors in the brain. So, although plant cannabinoids may interact with the same receptors as endogenous endocannabinoids, they also interact with other receptors. This is what causes the effects of endocannabinoids and plant cannabinoids in the body to differ.
The endocannabinoid system is the reason why CBD oil, gummies, and topicals have such a potent effect on the human body. The most important thing to note is that the human body produces similar effects as the body’s naturally-produced compounds.